Largeleaf Gentian Root

The root of Gentiana macrophylla mainly contains gentianine, gentianidine, gentianol, gentiopicroside, montanic acid, methyl montanate, α-amyrin, β-sitosterol and β-sitosterol-β-D-glucoside, etc.

This herb has anti-inflammatory, analgesic, antipyretic, diuretic, anti-anaphylactic, and antihistamine effects. It can also lower blood pressure, slow the heart rate, and raise blood glucose. Oral or intraperitoneal administration of gentianine A reduces spontaneous activity in mice and enhances the hypnotic effect of sodium pentobarbital in mice and rats. Gentianine A also strongly inhibits intestinal spasms induced by histamine and acetylcholine. The aqueous infusion inhibits dermatophytes, while the ethanolic extract inhibits Bacillus anthracis, Salmonella Paratyphi, Shigella, and staphylococci.

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